Literature summary for 2.3.1.108 extracted from

Wong, V.; Picci, C.; Swift, M.; Levinson, M.; Willis, D.; Langley, B.
alpha-Tubulin acetyltransferase s a novel target mediating neurite growth inhibitory effects of chondroitin sulfate proteoglycans and myelin-associated glycoprotein (2018), eNeuro, 5, e0240 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8K341	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	primary mouse cortical neuron	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
ATAT1	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	exposure of primary mouse cortical neurons to soluble chondroitin sulfate proteoglycans and myelin-associated glycoprotein substrates causes an acute and RhoA-kinase-dependent reduction in alpha-tubulin acetylation and Atat1 protein levels, without changes to either axonal histone deacetylase-6 levels or histonedeacetylase-6 activity. The chondroitin sulfate proteoglycans and myelin-associated glycoprotein-induced reduction in Atat1 occurs primarily in the distal and middle regions of neurites and reconstitution of Atat1, either by Rho-associated kinase inhibition or lentiviral-mediated Atat1 overexpression, can restore neurite growth. Chondroitin sulfate proteoglycans and myelin-associated glycoprotein signaling decreases Atat1 levels posttranscriptionally via a Rho-associated kinase-dependent increase in Atat1 protein turnover	Mus musculus

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Release 2023.1 (January 2023)